Preferred Label : Apraglutide;
NCIt definition : A synthetic, long-acting glucagon-like peptide-2 (GLP-2) agonist, with intestinotrophic
activity. Apraglutide is a synthetic 33 amino acid peptide with four amino acid substitutions
as compared to the native protein: alanine (Ala) to glycine (Gly) at position 2 (A2G),
methionine (Met) to the synthetic lysine analog, aminocaproic acid (Ahx) at position
10 (M10Ahx), asparagine (Asn) to D-phenylalanine (D-Phe) at position 11 (N11F), and
asparagine (Asn) to leucine (Leu) at position 16 (N16L). Following subcutaneous administration,
apraglutide, as an analog of natural GLP-2, selectively activates GLP-2 receptors
in the gastrointestinal (GI) tract, which stimulates intestinal growth, increases
intestinal fluid and nutrient absorption, promotes healing, and improves intestinal
epithelial integrity and function. As apraglutide becomes highly bound to plasma protein
and resistant to degradation by dipeptidyl peptidase-4 (DPP-4), this agent has a longer
half-life as compared to other GLP-2 agonists, which allows for less frequent dosing.;
UNII : CVQ1IAY2G6;
CAS number : 1295353-98-8;
NCI Metathesaurus CUI : CL1406000;
Origin ID : C171811;
UMLS CUI : C5419317;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
