Andexanet Alfa

Preferred Label : Andexanet Alfa;

NCIt synonyms : Factor Xa Recombinant Inactivated-zhzo; Coagulation Factor Xa (Recombinant), Inactivated-zhzo;

NCIt definition : A genetically modified variant of human factor Xa (FXa) protein, that may be used to reverse the anticoagulation effect of direct oral FXa inhibitors. Upon intravenous administration, andexanet alfa binds to the administered FXa inhibitor, thereby neutralizing the anticoagulant effect of the FXa inhibitor. Andexanet alfa also binds to and inhibits the activity of tissue factor pathway inhibitor (TFPI), thereby increasing tissue factor (TF)-initiated thrombin generation and promoting coagulation.;

UNII : BI009E452R;

CAS number : 1262449-58-0;

Drug name : Andexxa; Ondexxya;

Molecule name : PRT-4445; PRT 4445;

NCI Metathesaurus CUI : CL1405718;

Codes from synonyms : 211;

Details

Origin ID

C171753;

UMLS CUI

C4079904;

Automatic exact mappings (from CISMeF team)
- Andexanet alfa [ICD-11 Extension code]
Currated CISMeF NLP mapping
- Andexanet alfa (substance) [SNOMED CT concept]
- andexanet alfa [MeSH concept]
- andexanet alfa [ATC Code]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Andexanet alfa (substance) [SNOMED CT concept]
- Product containing andexanet alfa (medicinal product) [SNOMED CT concept]
- andexanet alfa [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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