NCIt definition : A human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor
(INSTI), that is used to treat HIV infection. Upon oral administration, bictegravir
inhibits the strand transfer activity of HIV-1 integrase, an HIV-1 coded enzyme that
is necessary for viral replication. Inhibition of integrase prevents the integration
of linear HIV-1 DNA into host genomic DNA.;