NCIt synonyms : Factor IX Recombinant Fc Fusion Protein; Coagulation Factor IX Recombinant Immunoglubulin G1 Fusion Protein; rFIXFc;
NCIt definition : A recombinant fusion protein composed of the Fc region of human immunoglobulin (Ig)
G1 covalently linked to a recombinant form of human blood coagulation factor IX (FIX)
that has structural and functional properties similar to endogenous Factor IX, that
can be used to treat hemophilia B (congenital factor IX deficiency; Christmas disease)
and other bleeding episodes. Upon administration, eftrenonacog alfa, by providing
and replacing missing factor IX needed for effective hemostasis, may normalize the
activated partial thromboplastin time (aPTT), increase blood clotting, and reduce
and control bleeding episodes. The Fc region of human IgG1 binds to the neonatal Fc
receptor (FcRn). As FcRn is part of a naturally occurring pathway that delays lysosomal
degradation of immunoglobulins by cycling them back into circulation, the Fc domain
is able to prolong the plasma half-life of eftrenonacog alfa.;