Preferred Label : Cedazuridine/Azacitidine Combination Agent ASTX030;
NCIt synonyms : Cedazuridine Azacitidine; AZA/CDZ Combination;
NCIt definition : An orally available fixed-dose combination agent containing cedazuridine, a cytidine
deaminase (CDA) inhibitor, and the cytidine antimetabolite azacitidine, with potential
antineoplastic activity. Upon oral administration of the cedazuridine/azacitidine
combination agent ASTX030, cedazuridine binds to and inhibits CDA, an enzyme primarily
found in the gastrointestinal (GI) tract and liver that catalyzes the deamination
of cytidine and cytidine analogs. This prevents the breakdown of azacitidine, increases
its bioavailability and efficacy while decreasing GI toxicity due to the administration
of lower doses of azacitidine. Azacitidine exerts its antineoplastic activity through
the incorporation of its triphosphate form into DNA, which inhibits DNA methyltransferase
(DNMT), thereby blocking DNA methylation and results in hypomethylation of DNA. This
interferes with DNA replication and decreases tumor cell growth.;
Molecule name : ASTX 030; ASTX-030;
NCI Metathesaurus CUI : CL1405630;
Origin ID : C171649;
UMLS CUI : C5417876;
Semantic type(s)
- concept_is_in_subset
- has_target
