NCIt synonyms : UDP Glucuronosyltransferase Family 1 Member A1 c.-3279T G; UGT1A1 c.-3279T G; UDP Glucuronosyltransferase Family 1 Member A1*60 Allele; UGT1A1*60; UDP Glycosyltransferase 1 Family, Polypeptide A1*60 Allele; UDP Glycosyltransferase 1 Family, Polypeptide A1 c.-3279T G;
NCIt definition : Human UGT1A1*60 allele is located in the vicinity of 2q37 and is approximately 13
kb in length. This allele, which encodes UDP-glucuronosyltransferase 1-1 protein,
plays a role in the catabolism of small lipophilic molecules. Homozygous expression
of the UGT1A1*60 allele is associated with Crigler-Najjar syndrome type II and heterozygous
expression is associated with Gilbert syndrome.;
NCIt note : UGT1A1*60 polymorphism is located in the non-coding upstream promoter region of the
UGT1A1 gene.;