BCMA/CD3e Tri-specific T-cell Activating Construct HPN217

Preferred Label : BCMA/CD3e Tri-specific T-cell Activating Construct HPN217;

NCIt synonyms : BCMA/CD3e TriTAC HPN217; BCMA/CD3e-specific TriTAC HPN217; TriTAC HPN217; Anti-BCMA/CD3e TriTAC HPN217; BCMA/CD3 Tri-specific T-cell Activating Construct HPN217;

NCIt definition : A recombinant antibody derivative composed of tri-specific T-cell activating construct (TriTAC) directed against the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; TNFRSF17), the epsilon domain of CD3 antigen (CD3e) found on T-lymphocytes, and albumin, with potential immunostimulating and antineoplastic activities. Upon administration, BCMA/CD3e TriTAC HPN217 targets and binds to BCMA on tumor cells and CD3e on cytotoxic T-lymphocytes (CTLs), thereby bringing BCMA-expressing tumor cells and CTLs together, which results in the CTL-mediated cell death of BCMA-expressing tumor cells. The albumin-binding domain targets and binds to serum albumin, thereby extending the serum half-life of HPN217. BCMA, a member of the tumor necrosis factor receptor superfamily (TNFRSF), is overexpressed on malignant plasma cells and plays a key role in plasma cell survival.;

Molecule name : HPN-217; HPN 217;

NCI Metathesaurus CUI : CL1405854;

Details

Origin ID

C171631;

UMLS CUI

C5417875;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tumor Necrosis Factor Receptor Superfamily Member 17 [NCIt concept]

Keyword's position in hierarchy(ies) :

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