Preferred Label : Ifinatamab Deruxtecan;
NCIt synonyms : Anti-B7-H3/DXd ADC DS-7300a; Anti-B7H3/DXd Antibody-drug Conjugate DS-7300a; Anti-B7-H3/DXd Antibody-drug Conjugate DS-7300a;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody against
the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) conjugated, via an enzymatically
cleavable tetrapeptide-based linker, to the cytotoxic DNA topoisomerase I inhibitor
and exatecan (DX-8951) derivative DXd (MAAA-1181a; MAAA-1181), with potential antineoplastic
activity. Upon administration of the anti-B7-H3/DXd ADC DS-7300a, the anti-B7-H3 antibody
targets and binds to B7-H3-expressing tumor cells. Upon cellular uptake and lysosomal
degradation of the linker, DXd targets and binds to DNA topoisomerase I, thereby stabilizing
the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition
of DNA replication and apoptosis. This inhibits the proliferation of B7-H3-expressing
tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory
protein superfamily, is overexpressed on certain tumor cell types and on various immune
cells. It plays a key role in tumor growth and immune responses. The ADC allows for
reduced systemic exposure and enhanced delivery of the cytotoxic agent DXd.;
UNII : C6I0GC0GX5;
CAS number : 2484870-92-8;
Molecule name : DS 7300a; DS-7300a; DS 7300; DS-7300;
NCI Metathesaurus CUI : CL1405790;
Origin ID : C171577;
UMLS CUI : C5706670;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
- has_target
