Aggressive Variant Prostate Carcinoma

Preferred Label : Aggressive Variant Prostate Carcinoma;

NCIt synonyms : Metastatic Aggressive Variant Prostate Cancer; Treatment-Related Anaplastic Prostate Cancer; AVPCa; Metastatic Aggressive Variant Prostate Carcinoma; Treatment-Related Anaplastic Prostate Carcinoma; Aggressive Variant Prostate Cancer; Anaplastic Prostate Carcinoma; Anaplastic Prostate Cancer;

NCIt definition : A lethal form of advanced castration-resistant prostate carcinoma that emerges in the later stages of castration-resistant treatment. It is an adaptive response to androgen receptor pathway inhibition. The morphologic features vary, ranging from poorly differentiated carcinomas to mixed adenocarcinoma-small cell carcinomas to pure small cell carcinomas expressing neuroendocrine markers. Clinically, it manifests with rapidly progressive disease, visceral or lytic bone metastases and bulky tumor masses. Molecular studies have shown the loss of tumor suppressor genes TP53 and RB1.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1405791;

Details

Origin ID

C171576;

UMLS CUI

C5417704;

Automatic exact mappings (from CISMeF team)
- carcinoma [MeSH Descriptor]
Disease excludes abnormal cell
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
Disease may have findings
- Mixed Malignant Epithelial Cell Population [NCIt concept]
- Neuroendocrine Differentiation [NCIt concept]
- Poorly Differentiated Lesion [NCIt concept]
- Small Cell Component Present [NCIt concept]
Has associated anatomic sites
- Genitourinary System [NCIt concept]
- Male Reproductive System [NCIt concept]
- Prostate Gland [NCIt concept]
- Reproductive System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
disease_has_finding
- Aggressive Clinical Course [NCIt concept]
- Carcinomatous Component Present [NCIt concept]
- Castration Resistance [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Metastatic Lesion [NCIt concept]
- Refractory Disease [NCIt concept]
- Secondary Lesion [NCIt concept]
- Unfavorable Clinical Outcome [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Prostatic Epithelium [NCIt concept]
disease_has_primary_anatomic_site
- Genitourinary System [NCIt concept]
- Male Reproductive System [NCIt concept]
- Prostate Gland [NCIt concept]
disease_may_have_molecular_abnormality
- RB1 Gene Inactivation [NCIt concept]
- TP53 Gene Inactivation [NCIt concept]

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