NCIt definition : A fully human monoclonal antibody directed against the cell surface receptor CD39
(cluster of differentiation 39; ectonucleoside triphosphate diphosphohydrolase-1;
NTPDase1; ENTPD1), with potential immunomodulating and antineoplastic activities.
Upon administration, perenostobart specifically binds to the CD39 antigen, thereby
preventing the conversion and degradation of adenosine triphosphate (ATP) to adenosine
monophosphate (AMP). This leads to an increase in the extracellular levels of immunogenic
ATP and a decrease in the levels of immunosuppressive adenosine within the tumor microenvironment
(TME). A high level of ATP increases pro-inflammatory cytokine levels and promotes
both T-cell proliferation and the stimulation of dendritic and other myeloid-derived
cells that are necessary for innate and adaptive immunity. CD39, a cell surface ectonucleosidase,
is upregulated on tumor cells as an immune evasion strategy. Blocking its action may
improve anti-tumor immune responses.;
UNII : O84ZK2F68E;
CAS number : 2643331-31-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2643331-31-9
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Semantic type(s)