Preferred Label : Personalized Neoantigen DNA Vaccine GNOS-PV01;
NCIt synonyms : Neoantigen Vaccine GNOS-PV01; Personalized Neoantigen-based Vaccine GNOS-PV01;
NCIt definition : A personalized cancer vaccine consisting of patient-specific neoantigen-coding DNA
plasmids, which are immunogenic and unique to the patient's tumor, with potential
immunomodulating and antineoplastic activities. Upon administration of GNOS-PV01,
the patient-specific neoantigens are translated in cells and elicit a specific and
potent cytotoxic T-lymphocyte (CTL) response against tumor cells expressing these
neoantigens, resulting in tumor cell lysis. Each patient specific formulation may
contain multiple DNA plasmids, and each plasmid may contain multiple neoantigen DNA
sequences, allowing the delivery of multiple neoantigen DNA sequences simultaneously.;
Molecule name : GNOS-PV01;
NCI Metathesaurus CUI : CL1405519;
Origin ID : C171430;
UMLS CUI : C5417867;
- Semantic type(s)
- concept_is_in_subset