Preferred Label : Microbiome GEN-001;
NCIt synonyms : Microbiome-based Therapeutic GEN-001;
NCIt definition : A microbiome therapeutic composed of a single-strain bacterium, isolated from the
gut of healthy donors, with potential anti-tumor and immunomodulating activities.
Upon oral administration, the metabolites of GEN-001 may activate dendritic cells
and macrophages in the gut and increase the expression of the cytokines interleukin-7
(IL-7) and interleukin-15 (IL-15), which stimulates the proliferation of natural killer
(NK) cells and memory CD8 T-cells. The memory T-cells enhance the secretion of the
cytokine interferon-gamma (IFN-g), which further potentiates the immune response against
tumor cells. This may increase tumor cell killing and decrease tumor cell proliferation.
GEN-001 may improve therapeutic responses to other therapies, such as anti-PD-1 therapy.;
Molecule name : GEN-001; GEN 001;
NCI Metathesaurus CUI : CL1405526;
Origin ID : C171422;
UMLS CUI : C5417865;
Semantic type(s)
- concept_is_in_subset
