Preferred Label : Plasmid DNA Vaccine pING-hHER3FL;
NCIt synonyms : pING-hHER3FL Vaccine;
NCIt definition : A plasmid DNA cancer vaccine encoding the tumor-associated antigen (TAA) human epidermal
growth factor receptor type-3 (HER-3; HER3), with potential antineoplastic and immunomodulating
activities. Upon intramuscular administration of the plasmid DNA vaccine pING-hHER3FL
and after cellular uptake by muscle cells, the plasmid DNA expresses HER-3 which,
may elicit both antigen-specific cytotoxic T-lymphocyte (CTL) and humoral immune responses
against tumor cells expressing HER-3. HER-3 plays a key role in tumor cell proliferation
and its overexpression is associated with poor prognosis. HER-3 is associated with
tumor cell resistance to anti-HER-2 therapeutics.;
Molecule name : pING-hHER3FL;
NCI Metathesaurus CUI : CL1405505;
Origin ID : C171387;
UMLS CUI : C5417861;
Semantic type(s)
- concept_is_in_subset
