Preferred Label : Interleukin-15 Agonist Fusion Protein SHR1501;
NCIt synonyms : Interleukin-15/Interleukin-15 Receptor Alpha Sushi Domain Fusion Protein SHR1501; IL-15 Agonist Fusion Protein SHR1501; IL-15 Super-agonist SHR1501;
NCIt related terms : SHR-1501;
NCIt definition : A human Fc fusion protein composed of the cytokine interleukin (IL)-15 cross-linked
with the high-affinity binding sushi domain of IL-15 receptor alpha (IL-15Ra), with
potential antineoplastic activity. Upon administration, SHR-1501 activates and increases
the levels of natural killer (NK) cells and memory CD8 T-cells without stimulating
regulatory T-cells (Tregs). The memory T-cells enhance the secretion of the cytokine
interferon-gamma (IFN-g), which further potentiates the immune response against tumor
cells. This may increase tumor cell killing and decrease tumor cell proliferation.
IL-15 regulates CD8 T and NK cell development, activation and proliferation. SHR1501
is more potent than unmodified IL-15 and does not require endogenous IL-15Ra for its
action. The Fc moiety allows for an extended half-life of SHR-1501 while cross linking
IL-15 with IL-15Ra sushi domain improves stability.;
UNII : S4NL6N7DWD;
Molecule name : SHR 1501; SHR-1501;
NCI Metathesaurus CUI : CL1405483;
Origin ID : C171385;
UMLS CUI : C5417860;
Semantic type(s)
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
