Preferred Label : IRDye800-labeled Heterodimeric Peptide KSP-QRH 919288G;
NCIt synonyms : IRDye800-labeled KSP/QRH Dimer; KSP-QRH-E3-IRDye800; KSP/QRH Peptide Dimer; Peptide 919288G;
NCIt definition : A heterodimeric peptide consisting of the heptapeptide monomers KSPNPRF (KSP) and
QRHKPRE (QRH) targeting human epithelial growth factor receptor type 2 (EGFR2; HER2;
ErbB2) and epidermal growth factor receptor (EGFR), with an E3 spacer, labeled with
the near-infrared (NIR) fluorophore IRDye800, with potential imaging activity using
the scanning fiber endoscope (SFE) imaging system. Upon spraying of the esophagus
with IRDye800-labeled heterodimeric peptide KSP-QRH 919288G, the heterodimeric peptide
moiety targets and binds to HER2 and EGFR expressed on dysplastic cells in the pre-cancerous
mucosa of the esophagus. Upon fluorescence imaging of the fluorophore IRDye800 with
the SFE probe, the HER-2- and EGFR-expressing dysplastic cells can be detected. EGFR
and HER2 are tyrosine kinase receptors that are overexpressed on the surfaces of various
tumor cell types, and they are expressed in esophageal dysplasia.;
Molecule name : 919288G;
NCI Metathesaurus CUI : CL1405491;
Origin ID : C171372;
UMLS CUI : C5417855;
Semantic type(s)
- concept_is_in_subset
