Preferred Label : Genetically Modified Interleukin-12 Transgene-encoding Bifidobacterium longum;
NCIt synonyms : Bifidobacterium longum Encoding IL-12; Genetically Modified IL-12 Transgene-encoding Bifidobacterium longum; bacTRL-IL-12;
NCIt definition : A live, genetically modified probiotic bacteria Bifidobacterium longum (B. longum)
engineered to deliver genetic material encoding the human pro-inflammatory transgene
interleukin-12 (IL-12), with potential immunoactivating activity. Upon administration
of genetically modified IL-12 transgene-encoding B. longum, the bacteria selectively
colonize hypoxic tumor tissues and deliver plasmid DNA encoding the IL-12 transgene
within the tumor microenvironment (TME). IL-12 is translated in cells and activates
the immune system by promoting the activation of natural killer cells (NK cells),
inducing secretion of interferon-gamma and promoting cytotoxic T-cell responses against
tumor cells. This may result in both immune-mediated tumor cell death and the inhibition
of tumor cell proliferation.;
NCI Metathesaurus CUI : CL1405492;
Origin ID : C171371;
UMLS CUI : C5419111;
Semantic type(s)
- concept_is_in_subset
