Preferred Label : Iodine I 131 IPA;
NCIt synonyms : 4-[131I]iodo-L-phenylalanine; 4-L-[131I]iodo-phenylalanine; Iodine-131 IPA; I-131 IPA; 131I-IPA;
NCIt definition : A radioconjugate consisting of the tumor-specific amino acid derivative 4-iodo-L-phenylalanine
labeled with iodine I 131, a beta emitting radionuclide, with potential antineoplastic
activity. Upon administration, iodine I 131 IPA actively crosses the blood-brain barrier
and accumulates specifically in gliomas, via the amino acid transport system l-amino
acid transporter 1 (LAT1) over-expressed in malignant glioma cells. where it delivers
a cytotoxic dose of beta radiation. Cells that are exposed to radiation may also release
potent toxins into the intracellular environment, leading to radiation-induced biological
bystander effects (RIBBE) and killing cells not directly exposed to the radiation.
Iodine I 131 IPA may also act synergistically with external irradiation due to its
radiosensitizing property.;
NCI Metathesaurus CUI : CL1405459;
Origin ID : C171348;
UMLS CUI : C5419095;
Semantic type(s)
- concept_is_in_subset
