NCIt definition : A humanized anti-factor XI (FXI) antibody, with potential anti-thrombotic activity.
Upon administration, gruticibart targets and binds to the apple 2 domain of FXI, thereby
preventing the binding of FXI to factor XIIa (FXIIa). This blocks factor XIIa-mediated
FXI activation without inhibiting FXI activation by thrombin or the procoagulant function
of FXIa. The abrogation of FXI activation prolongs the activated partial thromboplastin
time (aPTT), and reduces platelet and fibrin accumulation. This results in the inhibition
of contact activation-initiated blood coagulation and prevents thrombus formation.
FXI contributes to thrombotic disease while playing a limited role in normal hemostasis.
Activation of FXI is essential for thrombus growth and stabilization.;
Currated CISMeF NLP mapping