Preferred Label : Bispecific Antibody AGEN1223;
NCIt definition : A bispecific antibody that simultaneously binds to two different and as of yet undisclosed
antigens co-expressed specifically on tumor-infiltrating regulatory T-cells (Tregs),
with potential immunomodulating and antineoplastic activities. Upon administration,
AGEN1223 targets and binds to the two antigens co-expressed specifically on tumor-infiltrating
Tregs. This leads to the selective depletion of immunosuppressive Tregs in the tumor
microenvironment (TME), while sparing peripheral Tregs and effector T-cells, enhancing
the overall antitumor response. AGEN1223 may also co-stimulate antigen-specific effector
T-cells, resulting in tumor cell death.;
Molecule name : AGEN-1223; AGEN 1223;
NCI Metathesaurus CUI : CL1405398;
Origin ID : C171161;
UMLS CUI : C5417849;
Semantic type(s)
- concept_is_in_subset
