Preferred Label : Allogeneic Anti-BCMA-CAR T-cells PBCAR269A;
NCIt definition : A preparation of allogeneic, off-the-shelf, T-lymphocytes that have been genetically
modified using a proprietary synthetic nuclease-based system to express a chimeric
antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell maturation
antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with
potential immunostimulating and antineoplastic activities. Upon administration, allogeneic
anti-BCMA-CAR T-cells PBCAR269A specifically recognize and kill BCMA-expressing tumor
cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell
activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily
(TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant
plasma cells and plays a key role in plasma cell proliferation and survival.;
NCI Metathesaurus CUI : CL1405454;
Origin ID : C171066;
UMLS CUI : C5418990;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
