Preferred Label : Anti-CD37-CAR-expressing T-lymphocytes;
NCIt synonyms : Anti-CD37-CAR T-cells; Anti-CD37-CAR-T Cells; CAR-37 T Cells;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric
antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD37 (cluster
of differentiation 37), with potential immunostimulating and antineoplastic activities.
Upon administration, anti-CD37-CAR T-cells specifically recognize and kill CD37-expressing
tumor cells. CD37, a member of the tetraspanin superfamily of cell surface antigens,
is expressed in B-cell non-Hodgkin lymphomas (NHL), in chronic lymphocytic leukemia
(CLL), and in some cases of cutaneous and peripheral T-cell lymphomas. It plays a
key role in tumor cell proliferation.;
NCI Metathesaurus CUI : CL1383288;
Origin ID : C171034;
UMLS CUI : C5418966;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
