Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106CNCIt concept
Preferred Label : Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C;
NCIt synonyms : ImmTAC IMC-F106C; Immune Mobilizing Monoclonal TCR Against Cancer IMC-F106C; ImmTAC Molecule IMC-F106C;
NCIt definition : A T-cell re-directing bi-specific biologic composed of a modified form of human T-cell
receptor (TCR) specific for the tumor-associated antigen (TAA) preferentially expressed
antigen in melanoma (PRAME) and fused to an anti-CD3 single-chain variable fragment
(scFv), with potential antineoplastic activity. Upon administration of IMC-F106C,
the TCR moiety of this agent targets and binds to PRAME on tumor cells and the anti-CD3
scFv moiety binds to CD3- expressing T-lymphocytes. This selectively cross-links tumor
cells and T-lymphocytes and results in a CTL-mediated death of PRAME-expressing tumor
cells. The TAA PRAME is overexpressed by a variety of cancer cell types.;
Semantic type(s)