Preferred Label : Personalized Neoantigen DNA Vaccine GNOS-PVO2;
NCIt synonyms : Neoantigen Vaccine GNOS-PVO2;
NCIt definition : A personalized cancer vaccine consisting of patient-specific neoantigen-coding DNA
plasmids, which are immunogenic and unique to the patient's tumor, with potential
immunomodulating and antineoplastic activities. Upon intradermal delivery by electroporation
of GNOS-PVO2, the patient-specific neoantigens are translated in cells and elicit
a specific and potent cytotoxic T-lymphocyte (CTL) response against tumor cells expressing
these neoantigens, resulting in tumor cell lysis. Each patient specific formulation
may contain multiple DNA plasmids, and each plasmid may contain multiple neoantigen
DNA sequences, allowing the delivery of multiple neoantigen DNA sequences simultaneously.;
Molecule name : GNOS-PVO2;
NCI Metathesaurus CUI : CL1383225;
Origin ID : C170950;
UMLS CUI : C5418124;
Semantic type(s)
- concept_is_in_subset
