Preferred Label : Uridine Phosphorylase Inhibitor TK-112690;
NCIt synonyms : UPase Inhibitor TK-112690;
NCIt related terms : TK-112690;
NCIt definition : A 2,2'-anhydropyrimidine derivative and human uridine phosphorylase (UPase) inhibitor
that can be used to suppress mucositis induced by certain chemotherapeutics. Upon
administration of UPase inhibitor TK-112690 prior to the administration of certain
chemotherapeutic agents, such as methotrexate (MTX), this agent targets, binds to
and blocks the activity of UPase, thereby preventing the metabolic breakdown of uridine
into uracil. This increases the uridine levels in plasma and may prevent mucositis.
By rescuing normal tissue, TK-112690 may enhance the therapeutic index of the chemotherapeutic
agent. UPase plays a key role in in pyrimidine metabolism, and catabolizes uridine
into uracil and ribose-1-phosphate.;
UNII : GQZ99GWR3T;
CAS number : 22423-26-3;
Molecule name : TK-112690; TK 112690;
NCI Metathesaurus CUI : CL1383068;
Origin ID : C170912;
UMLS CUI : C5417832;
Semantic type(s)
- concept_is_in_subset
