Preferred Label : Anti-CD19/CD22 CAR NK Cells;
NCIt synonyms : Anti-CD19/Anti-CD22 CAR Natural Killer Cells; Anti-CD19/CD22 CAR-Natural Killer Cells; Anti-CD19/CD22 Chimeric Antigen Receptor-Natural Killer Cells; Anti-CD19/CD22 CAR-NK Cells;
NCIt definition : A preparation of natural killer (NK) cells engineered to express a chimeric antigen
receptor (CAR) specific for the tumor-associated antigens (TAAs) cluster of differentiation
19 (CD19) and CD22, with potential immunostimulating and antineoplastic activities.
Upon administration, the anti-CD19/CD22 CAR-NK cells target and bind to CD19 and CD22
expressed on the surface of tumor cells. This induces selective toxicity in tumor
cells expressing these TAAs. CD19 and CD22, both transmembrane phosphoglycoproteins
expressed on the surface of cells in the B lineage, are often overexpressed on malignant
B-cells. By simultaneously targeting two B-cell antigens, this preparation may minimize
relapse due to single antigen loss in patients with B-cell malignancies.;
NCI Metathesaurus CUI : CL1383046;
Origin ID : C170904;
UMLS CUI : C5418870;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
