Preferred Label : Anti-CD19 iCAR NK Cells;
NCIt synonyms : Anti-CD19 iCAR Natural Killer Cells; Anti-CD19 iCAR-NK Cells; Anti-CD19 Inhibitory Chimeric Antigen Receptor-Natural Killer Cells;
NCIt definition : A preparation of natural killer (NK) cells engineered to express an inhibitory chimeric
antigen receptor (iCAR) specific for the tumor-associated antigen (TAA) cluster of
differentiation 19 (CD19), with potential immunostimulating and antineoplastic activities.
Upon administration, anti-CD19 iCAR-NK cells recognize, bind to and induce selective
cytotoxicity in CD19-expressing tumor cells. The iCAR is designed to spare normal
cells from NK cell actions by including an inhibitory receptor that is activated upon
binding to antigens that are present on normal cells only. CD19 antigen is a B-cell
specific cell surface antigen expressed in all B-cell lineage malignancies.;
NCI Metathesaurus CUI : CL1383049;
Origin ID : C170903;
UMLS CUI : C5418869;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
