Preferred Label : Inactivated Oncolytic Virus Particle GEN0101;
NCIt synonyms : Inactivated HVJ-E Immunotherapy GEN0101; Inactivated HVJ Particle GEN0101; Inactivated HVJ-E GEN0101; HVJ-E; Non-replicating Oncolytic Virus Particle GEN0101; Inactivated Hemagglutinating Virus of Japan Envelope Immunotherapy GEN0101; Inactivated Hemagglutinating Virus of Japan Envelope GEN0101;
NCIt definition : An inactivated, non-replicating particle of hemagglutinating virus of Japan (HVJ),
an oncolytic virus of the paramyxovirus family, with potential immunostimulating and
antineoplastic activities. Upon intracutaneous administration, GEN0101 targets and
binds to the cytosolic nucleic acid receptor retinoic acid-inducible gene I (RIG-I).
This induces RIG-I-mediated signaling and a potent innate immune response against
tumor cells, leading to the activation of natural killer (NK) cells and cytotoxic
T-lymphocytes (CTL), and apoptosis in tumor cells. GEN0101 also activates dendritic
cells (DCs) to produce cytokine interleukin-6 (IL-6), suppressing the function of
regulatory T cells (Treg), a negative regulator of immune responses. The suppression
of Treg activity helps maintain the induced immune responses.;
Molecule name : GEN 0101; GEN-0101;
NCI Metathesaurus CUI : CL1383056;
Origin ID : C170893;
UMLS CUI : C5417824;
Semantic type(s)
- concept_is_in_subset
