NCIt definition : A fully human monoclonal antibody that targets the neonatal crystallizable fragment
receptor (FcRn), with potential immunomodulating activity. Upon administration, nipocalimab
targets and binds to FcRn at the immunoglobulin G (IgG) binding site, thereby preventing
the interaction between FcRn and the serum protein IgG. By preventing FcRn/IgG binding,
nipocalimab blocks the FcRn-mediated rescue of IgG, enables IgG degradation and prevents
IgG-mediated inflammation. IgG plays a key role in many autoimmune diseases and is
an important factor in inflammatory processes.;
Currated CISMeF NLP mapping