Interleukin-15/Interleukin-15 Receptor Alpha Complex-Fc Fusion Protein XmAb24306

Preferred Label : Interleukin-15/Interleukin-15 Receptor Alpha Complex-Fc Fusion Protein XmAb24306;

NCIt synonyms : IL15/IL15Ra Complex-Fc Fusion Protein XmAb24306; IL15/IL15Ra-Fc Fusion Protein XmAb24306;

NCIt definition : An interleukin (IL)-15/IL-15-receptor alpha (IL-15Ra) complex fused to a bispecific Fc domain, with potential antineoplastic activity. Upon administration, XmAb24306 stimulates the proliferation of natural killer (NK) cells and memory CD8 T-cells. The memory T-cells enhance the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates the immune response against tumor cells. This may increase tumor cell killing and decrease tumor cell proliferation. IL-15 regulates CD8 T and NK cell development, activation and proliferation. XmAb24306 does not require endogenous IL-15Ra for its activation.;

Molecule name : XmAb-24306; RO 7310729; XmAb 24306; RO-7310729;

NCI Metathesaurus CUI : CL1383037;

Details

Origin ID

C170890;

UMLS CUI

C5417822;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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