Preferred Label : Interleukin-15/Interleukin-15 Receptor Alpha Complex-Fc Fusion Protein XmAb24306;
NCIt synonyms : IL15/IL15Ra Complex-Fc Fusion Protein XmAb24306; IL15/IL15Ra-Fc Fusion Protein XmAb24306;
NCIt definition : An interleukin (IL)-15/IL-15-receptor alpha (IL-15Ra) complex fused to a bispecific
Fc domain, with potential antineoplastic activity. Upon administration, XmAb24306
stimulates the proliferation of natural killer (NK) cells and memory CD8 T-cells.
The memory T-cells enhance the secretion of the cytokine interferon-gamma (IFN-g),
which further potentiates the immune response against tumor cells. This may increase
tumor cell killing and decrease tumor cell proliferation. IL-15 regulates CD8 T and
NK cell development, activation and proliferation. XmAb24306 does not require endogenous
IL-15Ra for its activation.;
Molecule name : XmAb-24306; RO 7310729; XmAb 24306; RO-7310729;
NCI Metathesaurus CUI : CL1383037;
Origin ID : C170890;
UMLS CUI : C5417822;
Semantic type(s)
- concept_is_in_subset
