Preferred Label : Simmitinib;
NCIt definition : An orally bioavailable inhibitor of numerous tyrosine kinases (TKs) including fibroblast
growth factor receptor (FGFR), vascular endothelial growth factor receptor type 2
(VEGFR2; KDR), and colony stimulating factor 1 receptor (CSF1R; CSF-1R), with potential
antiangiogenic and antineoplastic activities. Upon oral administration, simmitinib
binds to and inhibits the activities of these TKs, thereby preventing both the activation
of downstream signaling pathways and the proliferation of tumor cells overexpressing
these TKs. FGFR, VEGFR2, and CSF1R are upregulated in a variety of cancer cell types
and play key roles in tumor cell proliferation, angiogenesis, and metastasis.;
Molecule name : SOMCL-15-290;
NCI Metathesaurus CUI : CL1383173;
Origin ID : C170763;
UMLS CUI : C5418777;
Semantic type(s)
- concept_is_in_subset
