Preferred Label : Lipid Nanoparticle Encapsulating Glutathione S-transferase P siRNA NBF-006;
NCIt synonyms : siRNA-based Lipid Nanoparticle NBF-006; Lipid Nanoparticle Encapsulating GSTP siRNA NBF-006; siRNA-based LNP NBF-006;
NCIt definition : A biodegradable, lyophilized lipid nanoparticle (LNP) encapsulating small interfering
ribonucleic acid (siRNA) directed against glutathione S-transferase P (GSTP), with
potential antineoplastic activity. Upon administration of LNP encapsulating GSTP siRNA
NBF-006, the LNP formulation delivers the siRNA particles to the tumor cells where
the GSTP siRNA targets and binds to GSTP mRNA. This results in the inhibition of the
translation and expression of GSTP and may inhibit proliferation of KRAS-overexpressing
tumor cells. GSTP, an enzyme overexpressed in many tumor cell types, is involved in
modulating MAP kinase-related cell-signaling pathways.;
Molecule name : NBF 006; NBF-006;
NCI Metathesaurus CUI : CL1383151;
Origin ID : C170753;
UMLS CUI : C5417811;
Semantic type(s)
- concept_is_in_subset
