Preferred Label : SDF-1 Receptor Antagonist PTX-9908;
NCIt synonyms : CXCR4 Antagonist CTCE-9908; SDF-1 Analog PTX-9908;
NCIt related terms : CTCE-9908;
NCIt definition : A stromal cell-derived factor 1 (SDF-1; CXCL12) analog and inhibitor of C-X-C chemokine
receptor type 4 (CXCR4), with potential antineoplastic activity. Upon administration,
PTX-9908 selectively targets and binds to CXCR4, thereby preventing the binding of
CXCR4 to its ligand SDF-1. This inhibits receptor activation and results in decreased
proliferation and migration of CXCR4-overexpressing tumor cells. The G protein-coupled
receptor CXCR4, which is overexpressed in several tumor cell types, promotes tumor
angiogenesis, tumor cell proliferation, survival, invasion and metastasis. SDF-1,
a major chemotactic factor, plays a key role in mediating cell trafficking via selective
binding to CXCR4.;
UNII : NF0BX95A31;
CAS number : 1030384-98-5;
Molecule name : PTX 9908; PTX-9908; CTCE 9908; CTCE-9908;
NCI Metathesaurus CUI : CL1383156;
Origin ID : C170746;
UMLS CUI : C5417808;
Semantic type(s)
- concept_is_in_subset
