Preferred Label : Liposomal Bcl-2 Antisense Oligonucleotide BP1002;
NCIt synonyms : L-Bcl-2 Antisense Oligonucleotide BP1002; Liposomal Bcl-2 Antisense BP1002;
NCIt definition : A liposomal-based nanoparticle composed of an uncharged P-ethoxy antisense oligodeoxynucleotide
(ODN) targeting Bcl-2 mRNA and incorporated in liposomes, with potential antineoplastic
activity. Upon administration of liposomal Bcl-2 antisense oligonucleotide BP1002,
this agent targets and hybridizes with Bcl-2 mRNA and inhibits the expression of Bcl-2
protein. This may induce tumor cell apoptosis of Bcl2-overexpressing tumor cells and
may decrease tumor cell proliferation. Bcl2, a protein involved in regulating programmed
cell death, is overexpressed in a wide variety of tumors. It promotes cellular survival
and inhibits apoptosis.;
Molecule name : BP-1002; BP 1002; BP-100-1.02;
NCI Metathesaurus CUI : CL1383140;
Origin ID : C170743;
UMLS CUI : C5417807;
Semantic type(s)
- concept_is_in_subset
