Preferred Label : Sabarubicin;
NCIt synonyms : (7S,9S)-7-{(4-O-(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)-2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)oxy}-6,9,11-trihydroxy-9-(hydroxyacetyl)-7,8,9,10-tetrahydrotetracene-5,12-dione;
NCIt related terms : MEN-10755;
NCIt definition : A disaccharide analogue of the anthracycline antineoplastic antibiotic doxorubicin.
Sabarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting
DNA replication and repair and RNA and protein synthesis. This agent also induces
apoptosis through a p53-independent mechanism. Sabarubicin is less cardiotoxic than
doxorubicin.;
Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called antitumor
antibiotics.;
UNII : XS499WOZ93;
InChIKey : VQHRZZISQVWPLK-UIRGBLDSSA-N;
CAS number : 211100-13-9;
Molecule name : BMS-195615; MEN-10755;
Chemical formula : C32H37NO13;
Codes from synonyms : CDR0000045542;
Origin ID : C1706;
UMLS CUI : C0664590;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
