Preferred Label : Nanrilkefusp Alfa;
NCIt synonyms : IL-15/IL-15 Receptor Alpha Sushi Domain Fusion Protein SO-C101; Interleukin-15/Interleukin-15 Receptor Alpha Sushi Domain Fusion Protein SOT101;
NCIt definition : A human fusion protein consisting of the cytokine interleukin (IL)-15 and the high-affinity
binding sushi domain of IL-15 receptor alpha (IL-15Ra), with potential antineoplastic
activities. Upon administration, nanrilkefusp alfa activates and increases the levels
of natural killer (NK) cells and memory CD8 T-cells. The memory T-cells enhance the
secretion of the cytokine interferon-gamma (IFN-g), which further potentiates the
immune response against tumor cells. This may increase tumor cell killing and decrease
tumor cell proliferation. IL-15 regulates CD8 T and NK cell development, activation
and proliferation. Nanrilkefusp alfa is more potent than unmodified IL-15 and does
not require endogenous IL-15Ra for its action.;
UNII : UM4VY7ZEC9;
CAS number : 1416390-27-6;
Molecule name : SO-C101; RLI-15; RLI 15; SO C101; SOT-101; SOT 101;
NCI Metathesaurus CUI : CL1382942;
Origin ID : C170516;
UMLS CUI : C5706665;
Semantic type(s)
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
