Preferred Label : Rasdegafusp Alfa;
NCIt synonyms : DEC-205/NY-ESO-1 Fusion Protein CDX-1401;
NCIt definition : A fusion protein consisting of a fully human monoclonal antibody directed against
the endocytic dendritic cell (DC) receptor, DEC-205, linked to the tumor-associated
antigen (TAA) NY-ESO-1 with potential immunostimulating and antineoplastic activities.
The monoclonal antibody moiety of rasdegafusp alfa1 binds to the endocytic DC receptor,
which may result in DC endocytic internalization of this agent, specifically delivering
the NY-ESO-1 moiety. DC processing of NY-ESO-1 may boost the immune system to mount
a cytotoxic T-lymphocyte response (CTL) against cancer cells expressing NY-ESO-1.
NY-ESO-1, a cell surface protein expressed in normal fetal and adult testes, is upregulated
in a variety of tumor cell types.;
UNII : SU9AMV39DB;
CAS number : 1587257-96-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1587257-96-2
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G-SRS /a ;
Molecule name : CDX-1401;
NCI Metathesaurus CUI : CL1382603;
Origin ID : C170362;
UMLS CUI : C5139855;
Semantic type(s)
- concept_is_in_subset
- has_target
