Preferred Label : Pegcrisantaspase;
NCIt synonyms : Pegylated Erwinia asparaginase; mPEG-R-crisantaspase; Pegylated Recombinant L-asparaginase Erwinia chrysanthemi;
NCIt definition : A recombinant, pegylated form of Erwinia asparaginase (crisantaspase), derived from
the bacterium Erwinia chrysanthemi and genetically engineered to be produced in Pseudomonas
fluorescens, with potential antineoplastic activity. Recombinant Erwinia asparaginase
hydrolyzes L-asparagine to L-aspartic acid and ammonia. This depletes cancer cells
of asparagine, which blocks protein synthesis and tumor cell proliferation. Asparagine
is critical to protein synthesis in cancer cells, which cannot synthesize this amino
acid due to the absence of the enzyme asparagine synthase. Recombinant Erwinia asparaginase
can be used as an alternative in patients who are hypersensitive to Escherichia (E.)
coli-derived asparaginase products.;
UNII : Y8KTZ6Y35U;
CAS number : 1448590-54-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1448590-54-2
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G-SRS /a ;
Drug name : Asparec;
Molecule name : JZP-416; JZP 416;
NCI Metathesaurus CUI : CL1382536;
Origin ID : C170297;
UMLS CUI : C5418502;
Semantic type(s)
- concept_is_in_subset
