Ozanimod - CISMeF

Preferred Label : Ozanimod;

NCIt definition : An orally bioavailable sphingosine-1-phosphate (S1P) receptors 1 (S1PR1, S1P1) and 5 (S1PR5, S1P5) modulator, with potential anti-inflammatory and immunomodulating activities. Upon oral administration, ozanimod selectively targets and binds to S1PR1 on lymphocytes and induces S1PR1 internalization and degradation. This results in the sequestration of lymphocytes in lymph nodes. By preventing egress of lymphocytes, ozanimod reduces both the amount of circulating peripheral lymphocytes and the infiltration of lymphocytes into target tissues. This prevents a lymphocyte-mediated immune response and may reduce inflammation. S1PR1, a G-protein coupled receptor, plays a key role in lymphocyte migration from lymphoid tissues. Modulation of S1PR5 by ozanimod may be neuroprotective.;

UNII : Z80293URPV;

InChIKey : XRVDGNKRPOAQTN-FQEVSTJZSA-N;

CAS number : 1306760-87-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1306760-87-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : RPC-1063; RPC 1063;

NCI Metathesaurus CUI : CL1382523;

Details

Origin ID

C170279;

UMLS CUI

C4278675;

Automatic exact mappings (from CISMeF team)
- Ozanimod [ICD-11 Extension code]
Currated CISMeF NLP mapping
- Ozanimod (substance) [SNOMED CT concept]
- ozanimod [MeSH Supplementary Concept]
- ozanimod [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Ozanimod (substance) [SNOMED CT concept]
- Product containing ozanimod (medicinal product) [SNOMED CT concept]
- ozanimod [MeSH Supplementary Concept]
- ozanimod [ATC Code]
Validated automatic mappings to BTNT
- ozanimod [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_salt_form
- Ozanimod Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Ozanimod Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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