Preferred Label : Otilimab;
NCIt synonyms : Immunoglobulin G1, Anti-(Human Granulocyte-Macrophage Colony-stimulating Factor) (Human
Monoclonal GSK3196165 Heavy Chain), Disulfide with Human Monoclonal GSK3196165 Lambda-chain,
Dimer;
NCIt definition : A fully human monoclonal antibody directed against the inflammatory mediator granulocyte-macrophage
colony stimulating factor (GM-CSF), with potential immunomodulating activity. Upon
administration, otilimab targets, binds to and neutralizes GM-CSF. This prevents the
binding of GM-CSF to its targeted inflammatory cells, and prevents proliferation and
activation of various immune cells, and subsequent release of cytokines and B- and
T-cell responses. GM-CSF, a monomeric glycoprotein functioning as a cytokine promoting
both proliferation and activation of macrophages and neutrophils. GM-CSF levels are
elevated in certain immune-mediated diseases. It increases the production of pro-inflammatory
mediators, such as cytokines, chemokines and proteases.;
UNII : Y8127R3VCH;
CAS number : 1638332-55-4;
Molecule name : GSK3196165; MOR103;
NCI Metathesaurus CUI : CL1382746;
Origin ID : C170271;
UMLS CUI : C4731002;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
