Preferred Label : Necuparanib;
NCIt synonyms : HSGAG Mimetic M402; Heparan Sulfate Glycosaminoglycan Mimetic M402;
NCIt definition : A low molecular weight heparin derivative and heparan sulfate proteoglycan (HSPG)
mimetic with no or minimal anticoagulant activity and potential antineoplastic activities.
Upon administration, necuparanib mimics HSPGs by binding to and inhibiting various
heparin-binding growth factors, chemokines, and cytokines such as VEGF, HGF, FGF2,
SDF-1a, heparanase and P-selectin all of which are essential for tumor angiogenesis
and metastasis to occur. This inhibits heparin binding growth factor-mediated signaling
and disrupts tumor-stromal interactions eventually leading to an inhibition of angiogenesis
and tumor cell progression. In addition, M402 may enhance the cytotoxic effect of
other chemotherapeutic agents.;
UNII : ULS0NT2D68;
CAS number : 1415139-34-2;
Molecule name : M402;
NCI Metathesaurus CUI : CL1382683;
Origin ID : C170206;
UMLS CUI : C5421283;
Semantic type(s)
- concept_is_in_subset
