Mecapegfilgrastim

Preferred Label : Mecapegfilgrastim;

NCIt definition : A long-acting, pegylated, recombinant analog of the endogenous human granulocyte colony-stimulating factor (G-CSF), with hematopoietic activity. Upon administration, mecapegfilgrastim binds to and activates specific cell surface receptors and stimulates neutrophil progenitor proliferation and differentiation, as well as selected neutrophil functions. This may decrease the duration and incidence of chemotherapy-induced neutropenia (CIN). Pegylation significantly increases the therapeutic half-life.;

UNII : I4QL0KKG3K;

CAS number : 1570067-55-8;

NCI Metathesaurus CUI : CL1382649;

Details

Origin ID

C170155;

UMLS CUI

C3179328;

Currated CISMeF NLP mapping
- Mecapegfilgrastim [SMS substance]
- pegylated granulocyte colony-stimulating factor [MeSH Supplementary Concept]
- pegylated granulocyte colony-stimulating factor [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- pegylated granulocyte colony-stimulating factor [MeSH Supplementary Concept]
- pegylated granulocyte colony-stimulating factor [MeSH concept]
chemical_or_drug_affects_cell_type_or_tissue
- Hematopoietic Stem Cell [NCIt concept]
chemical_or_drug_affects_gene_product
- GM-CSF Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Cytokine Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Cell Differentiation [NCIt concept]
- Receptor Activation Process [NCIt concept]
- Stimulation of Cell Proliferation [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients