Fitusiran - CISMeF

Preferred Label : Fitusiran;

NCIt definition : A small-interfering RNA (siRNA) directed against the human glycoprotein antithrombin (AT), with potential coagulant activity. Upon subcutaneous administration of fitusiran, the siRNAs bind to AT mRNAs, which may result in the inhibition of translation of the AT protein. By preventing AT expression, the coagulation factor thrombin is increased and activated, which leads to the conversion of fibrinogen to fibrin, and thus clot formation. This reduces bleeding in hemophilia and rebalances hemostasis.;

UNII : SV9W47ZLE1;

CAS number : 1499251-18-1;

Molecule name : ALN AT3SC; ALN-57213; ALN 57213; ALN-AT3SC;

NCI Metathesaurus CUI : CL1382465;

Codes from synonyms : 122376;

Details

Origin ID

C169984;

UMLS CUI

C5139801;

Currated CISMeF NLP mapping
- fitusiran [MeSH concept]
- fitusiran [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- fitusiran [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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