Preferred Label : Etidaligide;
NCIt synonyms : DNA Repair Inhibiting Oligonucleotide AsiDNA; DSBs Mimic; Oligonucleotide-mimicking Double-stranded DNA Breaks; DNA Repair Inhibiting Oligonucleotide;
NCIt definition : A preparation of cell-permeant, short double-stranded DNA fragment that mimics double-strand
breaks (DSBs) and linked to a cholesterol molecule, with potential antineoplastic
activity. Upon administration of etidaligide, the cholesterol moiety enables tumoral
and nuclear uptake of the DNA fragment, which mimics DNA DSBs. Inside the tumor cells,
the DNA fragment triggers false DNA break signals, and binds to and activates DNA
repair proteins including both poly (ADP-ribose) polymerase (PARP) and DNA-dependent
protein kinase (DNA-PK). This prevents the recruitment of these repair proteins at
the actual damage site and inhibits various DNA DSB repair pathways including homologous
recombination (HR) and non-homologous end joining (NHEJ). This promotes genetic instability
and enhances the accumulation of single and double strand DNA breaks, ultimately leading
to apoptosis.;
UNII : VHB1T5I5S1;
CAS number : 1974402-87-3;
Drug name : AsiDNA;
NCI Metathesaurus CUI : CL1382450;
Origin ID : C169969;
UMLS CUI : C5418379;
Semantic type(s)
- concept_is_in_subset
