Preferred Label : Efavaleukin Alfa;
NCIt synonyms : IL-2 Mutein/Fc Fusion Protein AMG 592; Interleukin-2-Fc Fusion Protein AMG 592; IL-2 Mutein Fc-fusion Molecule AMG 592;
NCIt definition : A recombinant fusion protein consisting of a variant form of the human cytokine interleukin
2 (IL-2; IL2), IL-2 mutein, fused to a human Fc molecule, with potential cell-protective
and anti-inflammatory activities. Upon intravenous administration of recombinant human
IL-2 mutein/Fc fusion protein AMG 592, the IL-2 mutein moiety binds to its receptors,
and activates IL-2-mediated signaling pathways. IL-2 mutein preferentially expands
and activates regulatory T-cells (Tregs), thereby preventing inadequate immune responses
and restoring immune homeostasis. This may help control or prevent inflammatory reactions
as seen in inflammatory-based diseases, such as autoimmune diseases and graft-versus-host
disease (GvHD). IL-2 mutein is less able to stimulate natural killer (NK) cells and
conventional T-cells, which may lead to reduced toxicity compared to treatment with
recombinant IL-2. Fusion to the Fc increases the stability and half-life of AMG 592.
Tregs play a key role in the prevention of inflammatory diseases and immune homeostasis.;
UNII : YNH9K62UXU;
CAS number : 2049067-94-7;
Molecule name : AMG-592; AMG 592;
NCI Metathesaurus CUI : CL1382426;
Origin ID : C169929;
UMLS CUI : C5418362;
Semantic type(s)
- concept_is_in_subset
