Preferred Label : Desidustat;
NCIt synonyms : N-(1-(Cyclopropylmethoxy)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine; Glycine, N-((1-(cyclopropylmethoxy)-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl)-;
NCIt definition : An orally bioavailable, hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor
(HIF-PHI), with potential anti-anemic and anti-inflammatory activities. Upon administration,
desidustat binds to and inhibits HIF-PH, an enzyme responsible for the degradation
of transcription factors in the HIF family under normal oxygen conditions. This prevents
HIF breakdown and promotes HIF activity. Increased HIF activity leads to an increase
in endogenous erythropoietin production, thereby enhancing erythropoiesis. It also
reduces the expression of the peptide hormone hepcidin, improves iron availability,
and boosts hemoglobin (Hb) levels. HIF regulates the expression of genes in response
to reduced oxygen levels, including genes required for erythropoiesis and iron metabolism.
In addition, HIF 1-alpha (HIF1A) may play a role in reducing inflammation during acute
lung injury (ALI) through HIF-dependent control of glucose metabolism in the alveolar
epithelium.;
UNII : Y962PQA4KS;
InChIKey : IKRKQQLJYBAPQT-UHFFFAOYSA-N;
CAS number : 1616690-16-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1616690-16-4
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G-SRS /a ;
NCI Metathesaurus CUI : CL1382226;
Origin ID : C169887;
UMLS CUI : C5198569;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
