Preferred Label : Cenicriviroc Mesylate;
NCIt definition : The mesylate salt form of cenicriviroc, an orally bioavailable, dual inhibitor of
human C-C chemokine receptor types 2 (CCR2; CD192) and 5 (CCR5; CD195), with potential
immunomodulating, anti-inflammatory and antiviral activities. Upon oral administration,
cenicriviroc specifically binds to and prevents the activation of both CCR2 and CCR5.
This inhibits the activation of CCR2/CCR5-mediated signal transduction pathways and
may inhibit inflammatory processes. The G-protein coupled chemokine receptors CCR2
and CCR5 are expressed on the surface of monocytes and macrophages and stimulate their
migration and infiltration; they play key roles in inflammation and autoimmune diseases.
In addition, cenicriviroc inhibits human immunodeficiency virus (HIV)-1 entry via
CCR5 coreceptor interaction.;
UNII : R96TV84T21;
InChIKey : IXPBPUPDRDCRSY-YLZLUMLXSA-N;
CAS number : 497223-28-6;
Molecule name : TAK 652; TBR 652; TBR-652; TAK-652;
NCI Metathesaurus CUI : CL1382178;
Origin ID : C169838;
UMLS CUI : C5418326;
Semantic type(s)
- concept_is_in_subset
