" /> Cariprazine Hydrochloride - CISMeF





Preferred Label : Cariprazine Hydrochloride;

NCIt synonyms : RGH-188 Hydrochloride;

NCIt related terms : Vraylar;

NCIt definition : The hydrochloride salt form of cariprazine, an orally bioavailable partial agonist of the dopamine D2 and D3 receptors, a partial agonist of the serotonin 1A (5-HT1A) receptor, and an antagonist of the serotonin 2A (5-HT2A) and 2B (5-HT2B) receptors, with antipsychotic activity. Although its exact mechanism of action in schizophrenia is unknown, it has been proposed that cariprazine's antipsychotic activity is mediated through a combination of agonist and antagonist activities at various dopamine and serotonin receptors, particularly through its partial agonist activity at central dopamine D2 and 5-HT1A receptors, and its antagonist activity at 5-HT2A receptor.;

UNII : KQD7C255YG;

InChIKey : GPPJWWMREQHLQT-BHQIMSFRSA-N;

CAS number : 1083076-69-0;

Drug name : Vraylar;

NCI Metathesaurus CUI : CL1382167;

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12/05/2025


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