NCIt definition : A human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor
(INSTI), that is used for pre-exposure prophylaxis (PrEP) to reduce the risk of sexually
acquired HIV-1 infection. Upon gluteal intramuscular administration, cabotegravir
binds to the active site of HIV integrase and inhibits the activity of HIV integrase,
an HIV-1 coded enzyme that is necessary for viral replication. Inhibition of integrase
prevents the integration of HIV-1 DNA into host genomic DNA.;