Alisporivir - CISMeF

Preferred Label : Alisporivir;

NCIt definition : A non-immunosuppressive analogue of cyclosporine A and an inhibitor of cyclophilins, with potential antiviral activity. Upon oral administration, alisporivir targets and inhibits human host cyclophilins, thereby inhibiting hepatitis C virus (HCV) replication in hepatocytes. Alisporivir may also inhibit the replication of various coronaviruses. In addition, it may inhibit mitochondrial cyclophilin-D, which regulates mitochondrial permeability transition pore (mPTP) opening. This may prevent cell death and tissue damage.;

UNII : VBP9099AA6;

InChIKey : OLROWHGDTNFZBH-XEMWPYQTSA-N;

CAS number : 254435-95-5;

Molecule name : Debio 025;

NCI Metathesaurus CUI : CL1382114;

Details

Origin ID

C169774;

UMLS CUI

C1567950;

Currated CISMeF NLP mapping
- alisporivir [MeSH Supplementary Concept]
- alisporivir [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- alisporivir [MeSH Supplementary Concept]
- alisporivir [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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