" /> Acebilustat - CISMeF





Preferred Label : Acebilustat;

NCIt definition : An orally bioavailable, small molecule inhibitor of the enzyme leukotriene A4 hydrolase (LTA4H), with potential anti-inflammatory activity. Upon oral administration, acebilustat targets and inhibits the activity of LTA4H, thereby inhibiting the synthesis of the pro-inflammatory mediator leukotriene B4 (LTB4). This may reduce inflammation in various inflammatory disorders including cystic fibrosis and serious pulmonary inflammatory diseases. LTA4H catalyzes a major and rate-limiting step in LTB4 production, and LTB4 plays an important role in pulmonary and systemic inflammation.;

UNII : J64RI4D29U;

InChIKey : GERJIEKMNDGSCS-DQEYMECFSA-N;

CAS number : 943764-99-6;

Molecule name : CTX-4430; EP-501;

NCI Metathesaurus CUI : CL1382259;

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24/05/2025


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