NCIt definition : An orally bioavailable, small molecule inhibitor of the enzyme leukotriene A4 hydrolase
(LTA4H), with potential anti-inflammatory activity. Upon oral administration, acebilustat
targets and inhibits the activity of LTA4H, thereby inhibiting the synthesis of the
pro-inflammatory mediator leukotriene B4 (LTB4). This may reduce inflammation in various
inflammatory disorders including cystic fibrosis and serious pulmonary inflammatory
diseases. LTA4H catalyzes a major and rate-limiting step in LTB4 production, and LTB4
plays an important role in pulmonary and systemic inflammation.;
UNII : J64RI4D29U;
InChIKey : GERJIEKMNDGSCS-DQEYMECFSA-N;
CAS number : 943764-99-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 943764-99-6
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